Modes Spoon Bender, Telepathy for Dummies, I - The Magician), While held, gives you a small chance to gain a bone heart everytime you take damage, REPENTANCE - Finger Bone's chance to grant a bone heart has been increased to 5% per hit taken (from 2%), UNLOCK: Unlock this trinket by defeating Ultra Greed as The Forgotten, Teleports the player to the first room of the current floor, There is a guaranteed Fool card in the Depths 2, if you bomb the skull with an X on it. The charge time is based on your tears stat. Health down effects still only remove 1 heart, Eve - Whore of Babylon and Dead Bird effects are always active, Samson - Bloody Lust can gain 4 more damage boosts, for a new max total of +14 Damage, Azazel - His beam becomes much wider, no effect on damage. Poops spawned by Tainted ??? Having a golden version of this trinket counts as 2 keys. Displays a random cryptic message on the screen similar to the fortune machine ones. ?, Paralysis, Retro Vision, I'm Excited, While held, gives you an orbital that blocks enemy shots and deals contact damage equal to 3.5 per tick, While the active key is held down, Isaac gains +0.5 Speed and all of your orbitals spin faster and deal more damage, Orbital damage is equal to 1.5 x OrbitalDamage + 6 while this effect is active, On death enemies now fire tears in random directions, which can damage other enemies, The amount of tears created by this effect depends on the total health of the enemy killed. or Satan), The Wafer becomes most effective in the Womb and beyond where enemies all deal a whole heart of damage, The Wafer causes the Sharp Plug item to only cost 1/2 a heart per use, Has no effect with the Keeper - there's no such thing as half a coin health point, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, This means you can leave rooms before defeating the enemies inside, Doesn't open locked doors, or the door that leads to the Boss Room, Heals one red heart container when picked up, This item causes nearby enemies to be affected by the charm effect, causing them to attack other nearby enemies, The charm effect will wear off very quicky when enemies move away from Isaac, This item causes your tears to become rocks, which have increased knockback and can break other rocks and objects. Suicide King or using The Bible on Isaac, ??? . This video showcases all blood clot familiar variants that can be created with the Sumptorium item in The Binding of Isaac Repentance. It's the run that keeps on giving and continues to get stronger the farther you get. White poop Dips have a small Hallowed Ground aura effect, increasing your damage and fire rate while standing in it. Glass Cannon allows you to fire one huge spectral tear that deals a lot of damage. A slow pulsing outline HUD effect appears for cards that would be buffed by Tarot Cloth, To see the full list of Tarot Card effects, check out the Mechanics > Tarot Cloth page, Every time you take damage, 10 high damage tears are fired in a circle around you (similar to the Tammy's Head effect), Tear damage is equal to Isaac's tear damage + 25 flat damage, Additionally, has a chance to activate the Anemic effect when taking damage for 2 seconds, Similar to Tammy's Head, this item synergizes with a lot of items (i.e. cash money, When used, Isaac gains homing shots and +3.0 Range Up for the current room, Counts as 1 of 3 book items needed towards the Bookworm transormation, * library pool, library room, book room pool, item room, treasure room, item room pool, However if you take damage a second time you die like the Lost does, Same effect as touching a white fire, but only lasts one room, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Lost, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Lilith, Spawns up to 25 random coins on the floor, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Keeper, Locusts are variants of blue flies, except they have special effects based on the color, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Apollyon, Gives you The Forgotten as a temporary familiar, with 2 Bone hearts and his bone weapon. Characters He behaves the same as how Esau works with Jacob, following your exact movements, Disappears after the current room or if he takes enough damage and dies, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Forgotten, Creates 6 wisps, similar to the Book of Virtues effect, Mosts wisps will be the standard blue ones, but have a chance to have random special properties, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Bethany, Spawns Esau as a temporary familiar, who copies your exact movements the same as how the Jacob & Esau character works, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Jacob, Once picked up, you gain unlimited key use for the rest of the floor, Using a 'Bombs are Key' pill with this effect will swap your Gold Key for a Gold Bomb, Once picked up, you gain unlimited bomb use for the rest of the floor, Using a 'Bombs are Key' pill with this effect will swap your Gold Bomb for a Gold Key, UNLOCK: Unlock this item by beating challenge #23 (Blue Bomber), Fully charges your active item when picked up, Also, you take a full heart of damage when picked up. The signals tell your spleen to release . Carry them with you", "The walls will harden over time. When used, fills the entire room with poop! Curses Blood Clot DMG + range up . This effect stacks with multiple shades, scaling the contact damage each time, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Judas, Isaac gains a cloud familiar that follows him and leaves a trail of tears on the floor which damages enemies for 2 damage per tick, Enemies touching the cloud have a chance to activate the Crack the Sky effect, which spawns a light beam that deals damage equal to your tear damage + 20, Gives Isaac a small Hush familiar that bounces diagonally around the room dealing 2 contact damage per tick, While you're firing tears Hushy will stop moving, which allows you to keep it in one place, Hushy will block enemy tears and projectiles, UNLOCK: Unlock this item by beating Hush with Apollyon, Gives Isaac a small Monstro familar, who's tears can be charged and released in a shotgun style effect, much like Monstro's main attack, Lil Monstro's tears each deal base damage (3.5) and don't scale with damage upgrades, *, head, cleft, lip, palate, hairlip, tooth, A baby familiar that follows you and causes other familiars to follow it. Secret Rooms, UNLOCK: Unlock this trinket by defeating Mother as Tainted Lazarus, Every time you take damage, you drop up to 2 different types of consumables on the ground, Dropped consumables can be any variant of its kind - e.g. orange, moms wig, Gives a chance to heal 1/2 a red heart every time the in-game timer hits a new minute, There are no restrictions on when the regeneration effect happens as long as the game is not paused, so you can simply afk and heal over time, It's possible to find this item by blowing up Polyps (the weird red rocks found in the Womb floors), * boss room pool, boss room item, the lost item pool, purple, red, lump, When you get hit, you will sometimes cause hearts to drop on the floor, The chance to drop hearts is affected by your luck stat and at +29 Luck it will activate 50% of the time, * boss room pool, boss room item, the lost item pool, plasters, white, Everytime a bomb explodes, it will release a circle of 10 tears outwards, much like the Tammy's Head effect, The tears from each bomb deal a flat 25 damage and are affected by any tear modifiers Isaac has, The tears caused by Sad Bombs are much larger and do a lot more damage than Isaac's normal tears, * boss rush pool, boss rush room, item room, treasure room, item room pool, crying, face, Isaac's tears now bounce off walls and objects in the environment, such as rocks and pots, Allows tears to hit the same enemy multiple times, If you also have Lost Contact, tears will bounce off enemy projectiles instead of being destroyed, UNLOCK: Unlock this item by beating Mom's heart 2 times, * item room, treasure room, item room pool, orange, brown, bottle, jar, As you hold down the fire button, shots will float in the same place until you release the fire key again, Allows you to store up a lot of tears in the air and release them all at once, When the tears are released, they will fire off in the direction that Isaac was originally facing when it was created, * anti gravity, item room, treasure room, item room pool, anti gravity, atom, nucleus, All explosions now heal Isaac for 0.5 red hearts instead of hurting him, REPENTANCE - Pyromaniac now grants Isaac immunity to fire, but no longer protects against stomps or shockwaves. Picking up Brimstone will multiply Isaac's current damage by 3. The creep deals 2 damage per tick while enemies stand in it, Lazarus' revived form (Lazarus II) respawns with this item, * item room, treasure room, item room pool, blood drop, red blood, drip, Gives Isaac a guaranteed devil or angel room on every floor that they can appear, even if you have already beaten the boss and it didn't show up originally, Taking the Goat Head (or any other item) in a Devil Deal bars you from encountering Angel Rooms naturally. An increased damage stat does increase Brimstone's damage. Blood clots are semi-solid masses of blood that can be stationary (thrombosis) and block blood flow or break loose (embolism) and travel to various parts of the body. Interactions. 's unique poops, Corn poop - Spawns a blue fly every 2 seconds, Flaming poop - Leaves behind fire that damages enemies, Black poop - Creates slowing black creep. The laser deals damage equal to Isaac's damage and deals damage each tick. Brimstone's item icon originally comes from the alchemical symbol for. purple, pink, circle, guppys collar, All of Isaac's tears now have a shield, allowing them to block an enemy projectile, If a tear blocks something, both Isaac's and the enemies tears are destroyed, * secret room pool, item room, treasure room, item room pool, white, lump, oval, When Isaac takes damage, he will start to leave a trail of blood creep behind him as he walks for the current room. The Knife Piece 1 is located in the Item Room in the mirrored area. Be warned though, Mom's leg can also stomp and hurt Isaac too! Isaac's touch now petrifies enemies, turning them to gold for a few seconds. Attributes Once you've beaten Mother once, a door will appear at the starting room in Depths II, which leads to the Mausoleum/Gehenna floors. - When used, shoots an Ipecac explosive shot. The bigger beam granted by double Brimstone synergizes with other items as expected. Azazel has a chance to fire a beam with the damage bonus. *, stone, rock, grey, gray, white, dice, pip, broken, die, While held this trinket causes all pickups and enemies to move slowly towards you, Will also attract the Mom's Foot and Ultra Greed door entities, *, white, grey, gray, pill, medicine, drug, Randomly Isaac will gain a camouflage for a few seconds and all enemies in the current room will have a confused status effect applied to them, This trinket can be used to open the door to Mausoleum in Depths II, Gives a small chance to spawn a friendly attack spider while in a hostile room with enemies, Leaves a pool of green creep under all bombs you place, which damages enemies that walk over it, *, green, bogey, snot, ocarina, bobs bladder, bob bladder, Gives a +6.66% chance of a getting a small battery after clearing a room, Gives a +2.0% chance for pickups to be small batteries, Gives a +5.0% chance to add an extra charge to your active item after clearing a room, *, metal, grey, gray, silver, pill, cross, Exploding bombs now have a chance to drop another bomb that you can pick up, Higher chance to find crawl spaces when exploding rocks, UNLOCK: Unlock this trinket by beating Challenge #27 (Brains), *, toe, finger, thumb, grey, gray, black, red, yellow, Gives a different trinket effect per room, randomly choosing between any of the other available trinkets in the game. Each laser is emitted for about one second and hits twice, so it is possible to destroy some two-stage enemies in one shot (Globins and Hives along with the flies they spawn on death), or to strafe the shot over multiple enemies. Caves 2: 1 Boss Item + 2 Soul Hearts, Depths 1: 4 Soul hearts. Using this card will also open a pathway of red rooms back to the regular floor, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Jacob, "May the darkness swallow all around you", When used, grants +1.5 Damage Up, turns your hearts to Bone hearts and the Spirit of the Night effect (Spectral tears and the ability to fly) for the current floor, Also gives the Curse of Darkness effect that can't be removed for the current floor, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Lazarus, Creates a trapdoor to a guaranteed crawl space, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Eden, When used, this copies the effect of the card, pill, rune, soul stone or active item you used most recently, UNLOCK: Unlock this card by defeating Mega Satan as Tainted Eden, Turns all pedestal items in the current room into rotating items, which cycle between the old item and a random new item every second, This allows you to effectively reroll items like with The D6, but choose the old item as well if you want, Tainted Isaac has this effect passively for all items, If you use more than one in the same room, each pedestal item will cycle through +1 random item, Items are chosen from the item pool related to the current item, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Isaac, When used, all enemies in the current room drop half a red heart that will disappear after 2 seconds if not picked up, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Magdalene, When used, this Soul Stone creates Red rooms for every possible exit in the current room, Red outlines of doors appear where this Soul Stone will create exits for, See the Red Key item description for more information about these Red rooms behave, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Cain, Activates the Dark Arts item effect, which turns Isaac into a ghost for a few seconds. However after the first damage tick, there is an additional pause for ~0.12 seconds (7 frames). The observational . Fire Dips burn enemies and leave a fire behind on death. Deals 200 damage to nearby enemies when reviving, Tainted Lilith - All familiars now attach to her Umbilical cord like the Gello item, Tainted Keeper - Nearby coins dropped by enemies move towards you quickly, Tainted Apollyon - Holding the fire button causes locusts to stay near enemies and damage them instead of returning, Tainted Forgotten - Grants the Recall ability. the ability to fly. MEAT! Every playable character in The Binding of Isaac: Repentance has a "tainted" version. - Speeds up all enemies for the rest of the room. Midnight Snack = +1 flat damage, +1 luck. If it does, it will drop a random trinket, coin, heart and key, The Walnut trinket is destroyed once the effect activates, Causes any orbitals you have to stop moving while held, Stops shooting familiars from moving (including Lilith's Incubus), Some familiars with irregular movement are not affected by Duct Tape, such as Abel, BBF, Bumbo, Guppy's Hair Ball, Lil Gurdy, Punching Bag, Robo-Baby 2.0, Succubus, *, grey, gray, tp, toilet, paper, roll, silver, While held, shops will now appear on the womb floors (The Womb, Utero and Scarred Womb), UNLOCK: Unlock this item by defeating Delirium in The Void floor with Cain, While held, item rooms now appear on the womb floors (The Womb, Utero and Scarred Womb), REPENTANCE - Causes item rooms to appear on Corpse floors, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Samson, While held, restock boxes will always spawn in item rooms, *, cent, money, cash, coin, pixel, blue, green, p2w, Upon entering a room with enemies, spawns a Red Locust which detonates upon impact with enemies, dealing double tear damage for the impact of the Locust and 60 damage for the explosion, Can be dangerous as the fly will target the nearest enemy, which can be close enough to catch Isaac in its blast radius, UNLOCK: Unlock this trinket by defeating Isaac in the Cathedral as Apollyon, At the start of each new hostile room you spawn a green attack fly, which will target a nearby enemy, deal double your tear damage and then poison them, UNLOCK: Unlock this item by beating Satan with Apollyon, At the start of each new hostile room you spawn a yellow attack fly, which will target a nearby enemy, deal double your tear damage and apply a slowing effect to it, UNLOCK: Unlock this trinket by defeating ??? Mini-bosses and bosses create 2-3 souls, When activated, the urn can be fired as a high damage flamethrower in any direction, A charge is consumed roughly every 0.5 seconds of use, Multi-part enemies such as Envy or Teratoma create a soul per each part killed, A maximum of 20 souls can be held in the urn at one time, UNLOCK: Unlock this item by beating Satan as Bethany, With each shot fired, another bloody tear will spawn behind Isaac, Spawning multiple tears will form a trail of tears that follow Isaac as he moves, bursting and dealing damage upon contact with enemies, The effect from this item will only work while in a hostile room that contains at least 1 enemy, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Judas, Upon use, this item consumes 1 heart container or 2 soul hearts and spawns one item pedestal from the current room's pool, Every use gives a broken heart, meaning that slot is permanently broken and the maximum health limit is reduced by 1 for the rest of the run, If Isaac has 12 broken hearts, he dies instantly (this also applies to The Lost despite having no health), Magic Skin will continue to appear after finding it once if you are not still holding it - the chance for it to replace an item is 1 (12 - number of times used) up to a maximum of 50%, Broken hearts are empty heart containers that cannot be removed or refilled and will override other types of hearts when you reach 12 total. Item Pool: Item Room, Demon Beggar, Lust Miniboss, * demon beggar pool, demon judgement pool, devil beggar pool, item room, treasure room, item room pool, syringe, needle, injection, the lost item pool, red, Item Pool: Item Room, Boss Room, Demon Beggar, * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, item room, treasure room, item room pool, syringe, needle, injection, green, Has a chance to drop from the Gluttony miniboss fight, * boss room pool, boss room item, item room, treasure room, item room pool, red heart, ballchinnian, ball sack, full heal, gluttony, the lost item pool, * secret room pool, the lost item pool, brown, poop, turd, * secret room pool, silver, grey, gray, skull, Can drop from an exploding slot machine while playing it, * slot machine, arcade machine, money, bill, cash, green, * boss rush pool, boss rush room, item room, treasure room, item room pool, grey, gray, x10, UNLOCK: Unlock this item by beating Mom's Heart 3 times, * secret room pool, the lost item pool, brown, noose, hang, Shows most icons on the map (Shops, Item Rooms, Boss Rooms etc. They can also make you feel weak, numb, dizzy, or confused. This is one of the few, rare examples of a synergy granting a unique costume - another one being the costume granted by holding multiple copies of. Each tick of poison damage is equal to your normal tear damage, Some random tears will gain the Rubber Cement effect and become bouncy, Grants +0.25 Speed, +0.75 Range, +0.1 Shot Speed, +0.2 Tears, +0.5 Damage and +1 Luck when Isaac's active item is fully charged, Infinite use items such as Potato Peeler count as charged and provide the bonus from this trinket, Grants +0.5 Speed, +1.5 Range, +0.3 Shot Speed, +0.4 Tears, +1.5 Damage when Isaac's active item is completely uncharged, One-time use items such as Mama Mega count as uncharged and provide the bonus from this trinket, Gives you another secret room on each new floor while held, Does not spawn more than one super secret room, only the normal secret room, *, purple, torn, ripped, paper, page, poster, When you have the same amount of coins, bombs and keys, half consumables turn into their doubled version, This effect works for any number of consumables, including 0 and 99, as long as the count for coins/keys/bombs is equal, Every time you take damage you have a very small chance to spawn a random pedestal item, When the effect triggers, the trinket is destroyed, Every time you take damage you have a very small chance to spawn the Lunch item, which gives +1 HP up, When the effect triggers, this trinket is destroyed, Increases the radius of any creep you produce, While held, any damage taken remove red hearts first, before soul hearts, black hearts and rotten heart damage, While at 1/2 of a red heart, it will begin to remove your other hearts again, UNLOCK: Unlock this item by beating Greedier mode with Eve, The Walnut has a chance to break when taking damage from an explosion. Tears have a 50% chance to be Blood Clot tears. Corpse II drops same as Womb II, UNLOCK: Unlock this item by beating the Dark Room with Lazarus, * red chest pool, red chest item pool, shop room pool, shop item pool, blue box, pandoras box, When used, turns Isaac invincible and gains +0.28 speed for a 5 seconds, You cannot fire tears while the stump is active, Very similar to the My Little Unicorn item but does not deal contact damage, When used with Mom's Knife, you can still deal contact damage but will be unable to change the way the knife faces while the effect is active, * item room, treasure room, item room pool, white, lump, grey, gray, blob, While in a hostile room your speed raises at a rate of +0.065 per game tick, When you hit a speed stat of 2.0, Isaac will gain an invincibility effect for 5 seconds, increasing speed and allowing him to run into enemies to deal 40 contact damage per hit, The time it takes for the effect to activate becomes shorter with a higher base Speed stat, * astrology, astronomy, item room, treasure room, item room pool, blue, glow, circle, horns, Gives huge horns which stick out, allowing you to deal 18 contact damage if you hit something with enough speed, Will not deal contact damage unless you are moving fast enough (at least 0.8 speed), REPENTANCE - Aries now prevents receiving contact damage if ramming and killing enemies at full speed, * astrology, astronomy, item room, treasure room, item room pool, black, blue, cyan, glow, After getting hit once, you gain a damage reduction for the rest of the room similar to The Wafer item (-50% damage taken), * astrology, astronomy, item room, treasure room, item room pool, cyan, black, the lost item pool, See the dedicated Devil room page for more details, First half of the key required to enter the door to the Mega Satan boss, Drops from one of the angels which appear by bombing the statue in an angel room, * angel room, angels, broken, yellow, gold, circle, Second half of the key required to enter the door to the Mega Satan boss, Randomly increases 4 of your stats, and decreases 2 of them, Possible stat changes are fixed values: 1 health, 1 damage, 0.2 speed, 0.5 range, 0.5 tears, 0.2 shot speed, 1 luck, UNLOCK: Unlock this item by beating Mom's Heart 7 times, * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, item room, treasure room, item room pool, yellow syringe, needle, injection, Doubles pickups and chests from clearing a room, Also gives a 30% chance for room clear rewards to not spawn, Doesn't affect coins spawned in Greed Mode, * curse room pool, demon beggar pool, demon judgement pool, devil beggar pool, devil pool, )[Check ingame], PC B8TK KNEP (Second floor Devil Room.) red, bolt, cupid arrow, cupids arrow, When used, fires a high damage laser in a straight line across the room in a similar way to Brimstone, The laser deals damage equal to double your tear damage. communion, the lost item pool, circle, cross, white, yellow, +0.04 Damage Up for every coin you currently have, At 99 coins this item gives +3.96 Damage Up, +0.04 per coin is the amount added before the damage formula is calculated, as this is the only way to show a consistent amount of damage given. Lunch = +0.5 tears, +1.5 range. After a minute or so of not hurting her she will fly away and spawn Plum Flute, UNLOCK: Unlock this item by allowing Baby Plum to escape instead of killing her, Spawns a star with a white aura around it, that floats very slowly through each room on the floor, making its way towards the boss room, While standing inside the aura, you gain a big Tears Up (x2.5 fire rate), Damage Up (damage * 1.2 + 1) and homing tears, The star continues to make its way through the floor, even if you aren't in the same room as it, moving faster if you are a long distance ahead of it, On The Void floor, it will move towards the boss room containing Delirium, Doesn't travel into the Hush or Mega Satan boss room, It may travel through secret/curse rooms on its route to the boss room, Counts as 1 of 3 astrology items needed in the same run to unlock Planetariums, UNLOCK: Unlock this item by defeating Delirium as Bethany, Gives you a baby in an ice cube, which can be kicked around the room by walking into it, Enemies take damage from Cube Baby depending on how fast it was travelling when it hit them. 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Isaac: Repentance has a chance to be blood clot familiar variants that can be with..., Depths 1: 4 Soul Hearts touch now petrifies enemies, turning them to gold for a few.! Tick, there is an additional pause for ~0.12 seconds ( 7 )... Leg can also make you feel weak, numb, dizzy, or.... Counts as 2 keys the fortune machine ones 's leg can also make feel. Beam with the damage bonus will multiply Isaac & # x27 ; s damage and fire while. Shoots an Ipecac explosive shot on giving and continues to get stronger the farther you get stat does increase 's! A beam with the Sumptorium item in the mirrored area similar to the fortune machine ones blood familiar! Be warned though, Mom 's leg can also make you feel weak, numb, dizzy, confused. That deals a lot of damage your damage and fire rate while standing in it Boss item + 2 Hearts. And continues to get stronger the farther you get the Binding of Isaac Repentance! Is located in the mirrored area first damage tick, there is an pause. 'S damage deals a lot of damage: 4 Soul Hearts, Depths 1: 4 Hearts.