You might want to check out Thorne Research, Quercetin Phytosome (250mg per caps. Similarly, post-run muscular pain, cramps, localized pain and the post-exercise recovery time were all considered better with the supplementation according to VAS scores (P<0.05). Quercetin. Results were that quercetin improved morning stiffness, morning pain and after-activity pain compared with placebo. The effects of quercetin supplementation on eccentric exercise-induced muscle damage. The individual triathlon training included repetition of the defined distances 8 times in 14 days in the same environment. Training was considered more valuable in the quercetin group compared with controls (P<0.05). 14 Bazzucchi I, Patrizio F, Ceci R, et al. There are several herbal phytosome materials with clinical research demonstrating improved bioavailability, including curcumin phytosome,27 silymarin phytosome,28 bergamot phytosome,29 green tea phytosome,30 among others. J Nutr 2007;137:2405-11. Quercetin's best known mechanism of action involves its ability to stabilize mast cell membranes‚ which in turns can decrease the release of histamine. For more than 30 years he has educated and trained natural product retailers and health care professionals, has researched and formulated natural products for dozens of dietary supplement companies, and has written articles on nutrition, herbal medicine, nutraceuticals and integrative health issues for trade, consumer magazines and peer-reviewed publications. Quercetin and plants that contain it have a certain following for treatment of various conditions – for example, capers are used in Iranian Traditional Medicine. This was seen in the aforementioned athletic performance study on standard quercetin in which subjects experienced a modest improvement in performance measured as a 4.7 percent increase in strength with 1,000 mg/day, while the other studies cited found no benefit. Using quercetin for allergies is one of the most common reasons people take this compound in supplement form. 2016 Science of Supplements: Winter Issue, 2018 Product Sales Training for Retailers, 2018 Science of Supplements: Summer Issue, 2018 Science of Supplements: Winter Issue, Prof. Gene Bruno, MS, MHS, RH(AHG)—Huntington University of Health Sciences. 2002;22:19-34. 2017;36(1):9-15. Annu Rev Nutr. Bio-Quercetin phytosome [providing 5 mg quercetin [from Japanese sophora concentrate (flower bud)], phosphatidylcholine complex [from sunflower]) 15 mg ** Other Ingredients. 2016;5(7). 16 Pelletier DM, Lacerte G, Goulet ED. Supports allergy sufferers by helping stabilize mast cell membranes that store and release histamine*. J Am Coll Nutr. J Strength Cond Res 2012;26 Suppl 2:S53-60. 11 Chopra M, Fitzsimons PE, Strain JJ, Thurnham DI, Howard AN. At the end of the study, subjective performance, post-training pain, cramps, time to full recovery and oxidative stress were measured. The crucial advantage that is attributable to Quercetin Phytosome is its advanced phytosome technology. Quercetin has a bitter flavor and is used as an ingredient in dietary supplements, beverages, and foods. In natural way, quercetin can control the blood pressure. 2017;49(2):115-121. The biological activities, chemical stability, metabolism and delivery systems of quercetin: a review. 1998 Dec;46(5):895-903. A phospholipid complex of quercetin (Quercetin Phytosome®) has been recently tested in humans to evaluate a possible improvement in oral bioavailability. When looking for new antiviral compounds aimed to counteract the COVID-19, a disease caused by the recently identified novel coronavirus (SARS-CoV-2), the knowledge of the main viral proteins is fundamental. 2020 Oct 5. doi: 10.23736/S1121-421X.20.02771-3. Nutr Res. Endocr Metab Immune Disord Drug Targets. A group of athletes used quercetin phytosome® supplementation (one tablet of 250 mg quercetin phytosome® twice daily). Molecular docking studies have highlighted that quercetin, a natural polyphenol belonging to the flavonol class, inhibits 3CLpro, PLpro and S proteins. Quercetin may improve inflammation, blood pressure, exercise performance, and blood sugar management. This article was originally published here Minerva Gastroenterol Dietol. 19 Larson A, Witman MA, Guo Y, et al. In addition to stabilizing mast cells, it has antioxidant and other beneficial effects. People use quercetin as a medicine. These forms are not as easily absorbed. Quercetin phytosome consists of quercetin … 2011;16(2):172-194. pii: e002713. You can change your mind at any time by clicking the unsubscribe link in the footer of any email you receive from us. Research31 was conducted to test the solubility and oral absorption of quercetin phytosome. In addition to stabilizing mast cells, it has antioxidant and other beneficial effects. Quercetin Phytosome offers advanced phytosome technology for optimal absorption.*. Alt Med Rev. It will happen by adequate supplementation by quercetin. Quercetin. In a meta-analysis17 of clinical studies, supplementation with 500-1,000 mg/day of quercetin for four to 10 weeks was shown to decrease systolic blood pressure by 3.04 mmHg and diastolic blood pressure by 2.63 mmHg compared with placebo—although just one of the studies included in this analysis was conducted on a hypertensive population.18 In other clinical research,19 patients with mild hypertension who took 1,095 mg/day of quercetin lowered their systolic and diastolic blood pressure by 7 mmHg and 3 mmHg, respectively. More on this later in the article during the discussion of quercetin phytosome. What is Quercetin Phytosome Used For? 13 Kelly GS. 6 Cao J, Zhang Y, Chen W, Zhao X. 2012;32(8):557-64. When considering that quercetin phytosome had up to 20 times greater absorption than standard quercetin, it seems likely that it will not only work better, but that a lower dose of quercetin phytosome will be needed to elicit the same or better results. 5 Ross JA, Kasum CM. Biophysical technics have then very recently confirmed that quercetin is reasonably a potent inhibitor of 3CLpro. 8 Wang W, Sun C, Mao L, Ma P, Liu F, Yang J, et al. Technically, the term quercetin should be used to describe the aglycone only; however, this is not always the case in research or in the supplement industry, where quercetin is occasionally used generically to refer to quercetin-type molecules, including its glycosides.13, In a clinical trial with 12 young men, supplementation with 1,000 mg/day of quercetin for 14 days significantly, but modestly, reduced muscle weakness associated with eccentric exercise-induced severe muscle damage when compared with placebo, and also increased performance, measured as isometric strength compared to baseline (+4.7 percent, p < 0.05).14 However, other clinical research in which the same daily dose was given did not find that quercetin improved athletic performance.15,16. After hydrolysis of the conjugated form (mainly glucuronide) of quercetin found in human plasma, the pharmacokinetics results have demonstrated an increased bioavailability rate by about 20-fold for total quercetin. 9 D’Andrea G. Quercetin: a flavonol with multifaceted therapeutic applications? 27 Cuomo J, Appendino G, Dern AS, Schneider E, McKinnon TP, Brown MJ, Togni S, Dixon BM. Horm Metab Res. 24 Kelly GS. Clin Chem. Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Altern Med Rev. In in-vitro or animal research, quercetin has been shown to inhibit histamine released by mast cells basophils, suggesting an anti-allergy effect. Quercetin will make our heart strongger. This limitation led to the development of quercetin phytosome (Quercefit, Indena). Quercetin's best known mechanism of action involves its ability to stabilize mast cell membranes, which in turns can decrease the release of histamine. Incidentally, ascorbic acid (vitamin C) and the bioflavonoid quercetin … Alt Med Rev 1998;3:140-3. Specifically, EMIQ® (Enzymatically Modified Isoquercitrin) has shown to reduce allergy symptoms, improve heart health and have a beneficial effect on weight management. In this pilot registry study, the effects of supplementation with quercetin phytosome (Quercefit, Indena) were evaluated in amateur triathlon athletes. Alt Med Rev. In addition, it may have brain-protective, anti … In cell cultures, quercetin has been shown to prevent viral entry and reduce the cytopathic effects of many viruses, including rhinovirus and … Dietary flavonoids: bioavailability, metabolic effects, and safety. Br J Nutr 2010;103:249-255. In a double-blind, randomized controlled trial,23 50 women with rheumatoid arthritis were supplemented with 500 mg/day of quercetin or placebo for eight weeks. 2015;106:256–71. People take quercetin to try to manage a variety of issues, including: Heart and vessel problems; Lowering blood pressure; Prostate infections Solubility was tested in simulated gastrointestinal fluids and oral absorption in a randomized crossover pharmacokinetic study of healthy volunteers. Nutrients. 10 Chondrogianni N, Kapeta S, Chinou I, Vassilatou K, Papassideri I, Gonos ES. In a preliminary prospective, double-blind, placebo-controlled trial,22 men with non-bacterial prostatitis received supplementation with 500 mg twice daily (1,000 mg/day total) of quercetin or placebo for one month. In the lab, quercetin stabilizes mast cells that release histamine, the principal mediator of reactions to pollen … Quercetin Phytosome offers advanced phytosome technology for optimal absorption. Quercetin’s antioxidant and anti-inflammatory properties can ease allergy symptoms. Quercetin reduces blood pressure in hypertensive subjects. Trends Food Sci Technol. With many potentially beneficial effects on human health, this flavonol has been the subject of various clinical studies, epidemiological studies, animal and in-vitro studies.7 Quercetin has been reported to exhibit antioxidant, antitumoral, antiinflammatory, antimicrobial, antibacterial and antiviral properties,8,9 as well as exerting anti-aging, antithrombotic, antiaggregatory and vasodilatory effects.10,11 However, it should be noted that the low solubility and low absorption of quercetin limits its practical use,12 so research has been directed into overcoming those liabilities. Oxidative stress was also reduced (P<0.05). Quercetin is a flavonoid that complements vitamin C’s health benefits. “Quercetin” derives from the Latin word “quercetum,” meaning “oak forest,” and as a flavonol, is not produced in the human body (Lakhanpal & Rai, 2007). 29 Mollace V, Scicchitano M, Paone S, et al. Effects of quercetin on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Gene Bruno, MS, MHS, the dean of academics for Huntington University of Health Sciences, is a nutritionist, herbalist, writer and educator. of highly absorbable quercetin). Quercetin was initially found to provide broad-spectrum protection against SARS coronavirus in the aftermath of the SARS epidemic that broke out across 26 countries in 2003.1,2,3 Now, some doctors are advocating its use against SARS-CoV-2, in combination with vitamin C, noting that the two have synergistic effects. We only need to consume the vegetable and fruits to get it. J Am Heart Assoc. It is found in many foods, including apples, onions, teas, berries, vegetables of the cabbage family, seeds, and nuts. ABSTRACT When looking for new antiviral compounds aim It’s used to lower blood pressure, control obesity, lower cholesterol, and protect against heart attacks and stroke. Specifically, one dose of standard quercetin (500 mg) and two different doses of quercetin phytosome (250 and 500 mg) were administered orally in volunteers of both sexes, aged 18-50. 4 MiNerVa Medica 287 Results in total, 48 subjects were enrolled (age range: 30-40 years). Quercetin is a plant flavonol from the flavonoid group of polyphenols. Widely distributed in the plant kingdom, quercetin is the most abundant of the flavonoid molecules. Vitamin C and Bio-Quercetin Phytosome is a high-potency vitamin C supplement with an ultra-absorbable form of quercetin, encased in a plant-derived phytosome delivery system. * Quercetin stabilizes the … Arthritis: The joints of arthritis sufferers become inflamed, resulting in pain. All subjects attended a baseline measurement run and a second final measurement run … Quercetin – other chances that it may be helpful in treating COVID-19. A control group did not use supplementation. [i] [ii] The likely antiviral properties of quercetin are anyway challenged by its very poor oral bioavailability profile and any attempt to overcome this limit should be welcome. In using the term “standard quercetin,” I’m referring to quercetin-type flavonols (primarily as quercetin glycosides). Phytother Res. In addition to stabilizing mast cells‚ it has antioxidant and other beneficial effects. Quercenase combines bromelain, a compound of protein-digesting enzymes, with a highly absorbable form of quercetin. Categorically, quercetin is a flavonol—one of six subclasses of flavonoid compounds1—that naturally occurs in a variety of plant-based foods and herbs, including onions, apples, berries, teas, tomatoes, broccoli, lettuce, red wine,2,3 Ginkgo biloba, St. John’s wort and American elder (Sambucus canadensis).4 Flavonoids also occur as either glycosides (with attached sugars [glycosyl groups]) or as aglycones (without attached sugars).5 In Western populations, estimated daily intake of quercetin-type flavonols is about 13.82 mg/day.6. J Nat Prod. Online ahead of print. Quercetin. 20 Rezvan N, Moini A, Janani L, et al. 2011 Apr 25;74(4):664-9. 2020 Oct 5. doi: 10.23736/S1121-421X.20.02771-3. A group of 23 athletes used quercetin phytosome (one tablet of 250 mg quercetin phytosome twice a day, with breakfast and dinner). In fact, based on the very high plasma levels of quercetin, quercetin phytosome had up to 20 times greater absorption than standard quercetin (P <0.0001). 25 Kelly GS. Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: nitric oxide. The quercetin is not need our order to control the blood pressure. 23 Javadi F, Ahmadzadeh A, Eghtesadi S, et al. J Clin Pharmacol 2012;52(6):940-6. A phospholipid complex of quercetin (Quercetin Phytosome®) has been recently tested in humans to evaluate a possible improvement in oral bioavailability. The major druggable targets of SARS-CoV-2 include 3-chymotrypsin-like protease (3CLpro), papain-like protease (PLpro), RNA-dependent 26 RNA polymerase, and spike (S) protein. 7 Kelly GS. Increase Endurance and Stamina 2011;16(2):172-194. Results demonstrated significant improvements in solubility with quercetin phytosome, as well as significant improvements in the oral absorption of quercetin phytosome. Eur J Drug Metab Pharmacokinet. 30 Pietta P, Simonetti P, Gardana C, Brusamolino A, Morazzoni P, Bombardelli E. Relationship between rate and extent of catechin absorption and plasma antioxidant status. It … 18 Edwards RL, Lyon T, Litwin SE, et al. Effect of quercetin on CYP3A activity in Chinese healthy participants. 21 Khorshidi M, Moini A, Alipoor E, et al. Overview Quercetin (3,3′,4′,5,7-pentahydroxyflavone) is one of the most abundant flavonoids present in over twenty plant and fruit categories. Likewise, in animal research, quercetin has been shown to have anti-asthmatic research and counter some aspects of anaphylactic reactions.24, In-vitro research indicates that quercetin has a variety of anticancer properties, including antioxidant, antiproliferative, pro-apoptotic, cell signaling effects and growth factor suppression, as well as potential synergism with some chemotherapeutic agents. Biochem Mol Biol Int. In the introduction, I mentioned that low solubility and low absorption of quercetin limits its practical use. Database (Oxford). 2011;16(2):172-194. The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake. pii: E205. Oxidative stress contributes to the development of … 2011;16(2):172-194. © Copyright 2020 Vitamin Retailer Magazine, Inc. All Rights Reserved. 2019 Apr;44(2):169-177. Fitoterapia. Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. By contrast, subjects using 500 mg/day of quercetin phytosome experienced an 11.3 percent increase in performance. The research generally suggest that quercetin helps modestly lower blood pressure. Quercetin. 2019;19(2):136-143. Phytosome is a food-grade delivery system designed and developed case-by-case for natural products. Alt Med Rev. 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A new quercetin phytosome provides approximately 50 times greater oral bioavailability compared to typical quercetin supplements.13 This enables 74 mg of this quercetin phytosome (providing 25 mg quercetin) to deliver a dose approximately equivalent to about 1,250 mg of typical quercetin. We use cookies to ensure that we give you the best experience on our website. 12 Wang W, Sun C, Mao L, Ma P, Liu F, Yang J, et al. Alt Med Rev. Effects of quercetin supplementation on endurance performance and maximal oxygen consumption: a meta-analysis. Peak Performance Quercetin Phytosome uses advanced phytosome technology, a process where quercetin is combined with sunflower-sourced phospholipids to create a bioavailable phytosome complex that … 17 Serban MC, Sahebkar A, Zanchetti A, et al; Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group. Effects of quercetin on adiponectin-mediated insulin sensitivity in polycystic ovary syndrome: A randomized placebo-controlled double-blind clinical trial.
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